The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK

• Main Authors: Leopoldo Raul Beltran (Author), Corinna eDawid (Author), Madeline eBeltran (Author), Guenter eGisselmann (Author), Katharina eDegenhardt (Author), Klaus eMathie (Author), Thomas eHofmann (Author), Hanns eHatt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For a long time, the focus of trigeminal chemoperception has rested almost exclusively on TRP channels. However, two-pore domain (K2P) potassium channels have recently been identified as targets for substances associated with typical trigeminal sensations, such as numbing and tingling. In addition,...