Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562

• 主要な著者: Nehad M. El-Dydamony (著者), Rana M. Abdelnaby (著者), Rasha Abdelhady (著者), Omaima Ali (著者), Mohamed I. Fahmy (著者), Rasha R. Fakhr Eldeen (著者), Amira A. Helwa (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

A novel series of 4-(4-Methoxyphenyl)-2-(methylthio)pyrimidine-5-carbonitrile was developed linked to an aromatic moiety via N-containing bridge and then evaluated for their cytotoxic activity against MCF-7 and K562 cell lines. Seven compounds exhibited the highest activity against both cell lines w...