Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562

• Main Authors: Nehad M. El-Dydamony (Author), Rana M. Abdelnaby (Author), Rasha Abdelhady (Author), Omaima Ali (Author), Mohamed I. Fahmy (Author), Rasha R. Fakhr Eldeen (Author), Amira A. Helwa (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel series of 4-(4-Methoxyphenyl)-2-(methylthio)pyrimidine-5-carbonitrile was developed linked to an aromatic moiety via N-containing bridge and then evaluated for their cytotoxic activity against MCF-7 and K562 cell lines. Seven compounds exhibited the highest activity against both cell lines w...