Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562

• Prif Awduron: Nehad M. El-Dydamony (Awdur), Rana M. Abdelnaby (Awdur), Rasha Abdelhady (Awdur), Omaima Ali (Awdur), Mohamed I. Fahmy (Awdur), Rasha R. Fakhr Eldeen (Awdur), Amira A. Helwa (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

A novel series of 4-(4-Methoxyphenyl)-2-(methylthio)pyrimidine-5-carbonitrile was developed linked to an aromatic moiety via N-containing bridge and then evaluated for their cytotoxic activity against MCF-7 and K562 cell lines. Seven compounds exhibited the highest activity against both cell lines w...