β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling

• Main Authors: Zhang-qi Cao (Author), Xue-xi Wang (Author), Li Lu (Author), Jing-wen Xu (Author), Xiao-bin Li (Author), Guang-ru Zhang (Author), Zhan-jun Ma (Author), An-chen Shi (Author), Yan Wang (Author), Yu-jun Song (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

β-sitosterol (BS), a major bioactive constituent present in plants, has shown potent anti-cancer activity against many human cancer cells, but its activity in pancreatic cancer (PC) cells has rarely been reported. Gemcitabine (GEM) is one of the first-line drugs for PC therapy, however, the treatmen...