Stereoselective metabolism of donepezil and steady-state plasma concentrations of S-donepezil based on CYP2D6 polymorphisms in the therapeutic responses of Han Chinese patients with Alzheimer's disease

• Main Authors: Jin Lu (Author), Lili Wan (Author), Yuan Zhong (Author), Qi Yu (Author), Yonglong Han (Author), Pengguo Chen (Author), Beiyun Wang (Author), Wei Li (Author), Ya Miao (Author), Cheng Guo (Author)
• Format: Book
• Published: Elsevier, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The therapeutic response rates of patients to donepezil vary from 20% to 60%, one of the reasons is their genetic differences in donepezil-metabolizing enzymes, which directly influence liver metabolism. However, the mechanism of donepezil metabolism and that of its enantiomers is unknown. This stud...