The Synthesis and Preclinical Investigation of Lactosamine-Based Radiopharmaceuticals for the Detection of Galectin-3-Expressing Melanoma Cells

• Main Authors: Barbara Gyuricza (Author), Ágnes Szűcs (Author), Judit P. Szabó (Author), Viktória Arató (Author), Zita Képes (Author), Dániel Szücs (Author), Dezső Szikra (Author), György Trencsényi (Author), Anikó Fekete (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Given that galectin-3 (Gal-3) is a β-galactoside-binding lectin promoting tumor growth and metastatis, it could be a valuable target for the treatment of Gal-3-expressing neoplasms. An aromatic group introduced to the C-3' position of lactosamine increased its affinity for Gal-3. Herein, we aim...