Extensor carpi ulnaris muscle shows unexpected slow-to-fast fiber-type switch in Duchenne muscular dystrophy dogs

• Main Authors: Chady H. Hakim (Author), Hsiao T. Yang (Author), Matthew J. Burke (Author), James Teixeira (Author), Gregory J. Jenkins (Author), N. Nora Yang (Author), Gang Yao (Author), Dongsheng Duan (Author)
• Format: Book
• Published: The Company of Biologists, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aged dystrophin-null canines are excellent models for studying experimental therapies for Duchenne muscular dystrophy, a lethal muscle disease caused by dystrophin deficiency. To establish the baseline, we studied the extensor carpi ulnaris (ECU) muscle in 15 terminal age (3-year-old) male affected...