Microarray Analysis of Glomerular Gene Expression in Murine Lupus Nephritis

• Main Authors: Kae Teramoto (Author), Nobuo Negoro (Author), Kouichirou Kitamoto (Author), Tomoaki Iwai (Author), Hiroshi Iwao (Author), Mikio Okamura (Author), Katsuyuki Miura (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To elucidate the molecular mechanism of glomerular events in lupus nephritis, we performed genome-wide mRNA expression analysis of glomeruli microdissected from lupus mice. MRL/lpr mice (12-week-old) were orally given vehicle or prednisolone (10 mg/kg per day) for 4 weeks. Renal histology of MRL/lpr...