Specific HER2 Exon 20 Gly776 Deletion-Insertions in Non-Small Cell Lung Cancer: Structural Analysis and Sensitivity to HER2-Targeted Tyrosine Kinase Inhibitors

• Main Authors: Guangjian Yang (Author), Haiyan Xu (Author), Jiaqi Hu (Author), Runze Liu (Author), Peizeng Hu (Author), Yaning Yang (Author), Weihua Li (Author), Xuezhi Hao (Author), Shuyang Zhang (Author), Fei Xu (Author), Xin Ai (Author), Junling Li (Author), Yan Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background:HER2 exon 20 insertions remain a subset heterogeneous alterations in lung cancer, with currently unmet need for precision targeted therapy. G776delinsVC, a typical HER2 exon 20 deletion-insertion at codon Gly776, was reported to respond discrepantly to afatinib compared with the predomina...