Genetic activation of Nrf2 reduces cutaneous symptoms in a murine model of Netherton syndrome

• Main Authors: Sukalp Muzumdar (Author), Michael Koch (Author), Hayley Hiebert (Author), Andreas Bapst (Author), Alessia Gravina (Author), Wilhelm Bloch (Author), Hans-Dietmar Beer (Author), Sabine Werner (Author), Matthias Schäfer (Author)
• Format: Book
• Published: The Company of Biologists, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Netherton syndrome is a monogenic autosomal recessive disorder primarily characterized by the detachment of the uppermost layer of the epidermis, the stratum corneum. It results from mutations in the SPINK5 gene, which codes for a kallikrein inhibitor. Uncontrolled kallikrein activity leads to prema...