Genetic activation of Nrf2 reduces cutaneous symptoms in a murine model of Netherton syndrome

• Hlavní autoři: Sukalp Muzumdar (Autor), Michael Koch (Autor), Hayley Hiebert (Autor), Andreas Bapst (Autor), Alessia Gravina (Autor), Wilhelm Bloch (Autor), Hans-Dietmar Beer (Autor), Sabine Werner (Autor), Matthias Schäfer (Autor)
• Médium: Kniha
• Vydáno: The Company of Biologists, 2020-05-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Netherton syndrome is a monogenic autosomal recessive disorder primarily characterized by the detachment of the uppermost layer of the epidermis, the stratum corneum. It results from mutations in the SPINK5 gene, which codes for a kallikrein inhibitor. Uncontrolled kallikrein activity leads to prema...