Brain Kynurenine Pathway Metabolite Levels May Reflect Extent of Neuroinflammation in ALS, FTD and Early Onset AD

• Autores principales: Annelies Heylen (Autor), Yannick Vermeiren (Autor), Ido P. Kema (Autor), Martijn van Faassen (Autor), Claude van der Ley (Autor), Debby Van Dam (Autor), Peter P. De Deyn (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2023-04-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Objectives: Despite distinct clinical profiles, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients share a remarkable portion of pathological features, with a substantial percentage of patients displaying a mixed disease phenotype. Kynurenine metabolism seems to play a ro...