Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization

Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization

Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to enhance their pharmacokinetic, pharmacodynamic and/or biopharmaceutical properties. Ideally, prodrugs are efficiently converted in vivo, through chemical or enzymatic transformations, to the active parent mole...

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Main Authors: Rebecca Nofsinger (Author), Sophie-Dorothee Clas (Author), Rosa I. Sanchez (Author), Abbas Walji (Author), Kimberly Manser (Author), Becky Nissley (Author), Jaume Balsells (Author), Amrithraj Nair (Author), Qun Dang (Author), David Jonathan Bennett (Author), Michael Hafey (Author), Junying Wang (Author), John Higgins (Author), Allen Templeton (Author), Paul Coleman (Author), Jay Grobler (Author), Ronald Smith (Author), Yunhui Wu (Author)
Format: Book
Published: MDPI AG, 2014-02-01T00:00:00Z.
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3rd Floor Main Library

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