Generation of functional human hepatocytes in vitro: current status and future prospects

• Main Authors: Tomoko Yamaguchi (Author), Juntaro Matsuzaki (Author), Takeshi Katsuda (Author), Yoshimasa Saito (Author), Hidetsugu Saito (Author), Takahiro Ochiya (Author)
• Format: Book
• Published: BMC, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Liver and hepatocyte transplantation are the only effective therapies for late-stage liver diseases, in which the liver loses its regenerative capacity. However, there is a shortage of donors. As a potential alternative approach, functional hepatocytes were recently generated from various c...