Lack of μ-Opioid Receptor-Mediated G-Protein Activation in the Spinal Cord of Mice Lacking Exon 1 or Exons 2 and 3 of the MOR-1 Gene

• मुख्य लेखकों: Hirokazu Mizoguchi (लेखक), Hsiang-En Wu (लेखक), Minoru Narita (लेखक), Ichiro Sora (लेखक), F. Scott Hall (लेखक), George R. Uhl (लेखक), Horace H. Loh (लेखक), Hiroshi Nagase (लेखक), Leon F. Tseng (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2003-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

ABSTRACT: The G-protein activation induced by μ-opioid receptor agonists was determined in spinal cord membranes from two types of μ-opioid receptor knockout mice: mice with a disruption of exon 1 (MOR (Exon 1)-KO) or exons 2 and 3 (MOR (Exons 2 and 3)-KO) of the μ-opioid receptor gene. The G-protei...