The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity

• Príomhchruthaitheoirí: Godefridus J. Peters (Údar), Ietje Kathmann (Údar), Elisa Giovannetti (Údar), Kees Smid (Údar), Yehuda G. Assaraf (Údar), Gerrit Jansen (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

BackgroundL-Leucovorin (l-LV; 5-formyltetrahydrofolate, folinic acid) is a precursor for 5,10-methylenetetrahydrofolate (5,10-CH2-THF), which is important for the potentiation of the antitumor activity of 5-fluorouracil (5FU). LV is also used to rescue antifolate toxicity. LV is commonly administere...