Inhibitory Effect of Imperatorin on the Pharmacokinetics of Diazepam In Vitro and In Vivo

• Main Authors: Yunfang Zhou (Author), Deru Meng (Author), Feifei Chen (Author), Zhengping Wu (Author), Binglan Wang (Author), Shuanghu Wang (Author), Peiwu Geng (Author), Dapeng Dai (Author), Quan Zhou (Author), Weiwen Qiu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundDiazepam is a benzodiazepine drug used to treat anxiety, insomnia, and muscle spasms. Imperatorin is a phytochemical isolated from medicinal plants and is widely used in herbal medicine. The aim of this study was to investigate the interactions between imperatorin and diazepam in vitro and...