Synthesis, In Vitro Antiproliferative Activity, and In Silico Evaluation of Novel Oxiranyl-Quinoxaline Derivatives

• Główni autorzy: Vincent Montero (Autor), Marc Montana (Autor), Omar Khoumeri (Autor), Florian Correard (Autor), Marie-Anne Estève (Autor), Patrice Vanelle (Autor)
• Format: Książka
• Wydane: MDPI AG, 2022-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The quinoxaline core is a promising scaffold in medicinal chemistry. Multiple quinoxaline derivatives, such as the topoisomerase IIβ inhibitor XK-469 and the tissue transglutaminase 2 inhibitor GK-13, have been evaluated for their antiproliferative activity. Previous work reported that quinoxaline d...