From investigational product to active reference: evolution of oral sumatriptan efficacy versus placebo for the treatment of acute migraine episodes and potential impact in comparative analyses

• Auteurs principaux: Katia Thokagevistk (Auteur), Clément François (Auteur), Mélanie Brignone (Auteur), Mondher Toumi (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Background: The relative efficacy and safety can vary among drugs over time. Sumatriptan, a first choice drug for acute migraine, can illustrate this phenomenon. Objective: To assess the evolution of the relative efficacy and tolerability of oral sumatriptan against placebo between its approval in 1...