Adipose retinol saturase is regulated by β-adrenergic signaling and its deletion impairs lipolysis in adipocytes and acute cold tolerance in mice

• Main Authors: Chen Li (Author), Marie F. Kiefer (Author), Sarah Dittrich (Author), Roberto E. Flores (Author), Yueming Meng (Author), Na Yang (Author), Sascha Wulff (Author), Sabrina Gohlke (Author), Manuela Sommerfeld (Author), Sylvia J. Wowro (Author), Konstantin M. Petricek (Author), Dominic Dürbeck (Author), Leonard Spranger (Author), Knut Mai (Author), Holger Scholz (Author), Tim J. Schulz (Author), Michael Schupp (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Retinol saturase (RetSat) is an endoplasmic reticulum-localized oxidoreductase highly expressed in organs involved in lipid metabolism such as white (WAT) and brown adipose tissue (BAT). Cold exposure was shown to increase RETSAT protein in BAT but its relevance for non-shivering thermoge...