TMBur: a distributable tumor mutation burden approach for whole genome sequencing

• Main Authors: Emma Titmuss (Author), Richard D. Corbett (Author), Scott Davidson (Author), Sanna Abbasi (Author), Laura M. Williamson (Author), Erin D. Pleasance (Author), Adam Shlien (Author), Daniel J. Renouf (Author), Steven J. M. Jones (Author), Janessa Laskin (Author), Marco A. Marra (Author)
• Format: Book
• Published: BMC, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Tumor mutation burden (TMB) is a key characteristic used in a tumor-type agnostic context to inform the use of immune checkpoint inhibitors (ICI). Accurate and consistent measurement of TMB is crucial as it can significantly impact patient selection for therapy and clinical trial...