Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer's Disease

• Main Authors: Erica Staurenghi (Author), Gabriella Testa (Author), Valerio Leoni (Author), Rebecca Cecci (Author), Lucrezia Floro (Author), Serena Giannelli (Author), Eugenio Barone (Author), Marzia Perluigi (Author), Gabriella Leonarduzzi (Author), Barbara Sottero (Author), Paola Gamba (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Down syndrome (DS) is a complex chromosomal disorder considered as a genetically determined form of Alzheimer's disease (AD). Maintenance of brain cholesterol homeostasis is essential for brain functioning and development, and its dysregulation is associated with AD neuroinflammation and oxidat...