Validation of a liquid chromatographic method for determination of related substances in a candidate certified reference material of captopril

• Main Authors: Raquel Nogueira (Author), Wagner Wollinger (Author), Thaís Elias da Silva (Author), Leonardo Mesquita de Oliveira (Author), Eliane Cristina Pires do Rego (Author), Gabriela Fernandes Moreira (Author), Juliano Smanioto Barin (Author), Luciane Varini Laporta (Author), Márcia Foster Mesko (Author), Celso Figueiredo Bittencourt (Author), Janaína Marques Rodrigues (Author), Valnei Smarçaro da Cunha (Author)
• Format: Book
• Published: Universidade de São Paulo, 2011-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This paper describes the validation of a reversed-phase high performance liquid chromatography method (RP-HPLC) with diode array detection (DAD) for determination of related substances (impurities from organic synthesis and degradation products) of captopril according to the Brazilian Pharmacopeia I...