Potential Protective Effect of Orlistat: A Formulation of Nanocrystals Targeting Inflammation, Oxidative Stress, and Apoptosis in an Experimental Model of Doxorubicin-Induced Cardiotoxicity

• Váldodahkkit: Maha Alsunbul (Dahkki), Thanaa A. El-Masry (Dahkki), Enas I. El Zahaby (Dahkki), Mohamed M. S. Gaballa (Dahkki), Maysa M. F. El-Nagar (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2024-10-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

<b>Background</b>: Doxorubicin (DOX) is a widely used chemotherapeutic agent; nevertheless, cardiotoxicity limits its effectiveness. Orlistat (Orli) is an irreversible lipase enzyme inhibitor with poor solubility and bioavailability. Furthermore, Orli has a favorable impact on the decrea...