Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice

• Main Authors: Sigrid Jall (Author), Stephan Sachs (Author), Christoffer Clemmensen (Author), Brian Finan (Author), Frauke Neff (Author), Richard D. DiMarchi (Author), Matthias H. Tschöp (Author), Timo D. Müller (Author), Susanna M. Hofmann (Author)
• Format: Book
• Published: Elsevier, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity is a major health threat that affects men and women equally. Despite this fact, weight-loss potential of pharmacotherapies is typically first evaluated in male mouse models of diet-induced obesity (DIO). To address this disparity we herein determined whether a monomeric peptide wi...