Assay format diversity in pre-clinical immunogenicity risk assessment: Toward a possible harmonization of antigenicity assays

• Main Authors: Axel Ducret (Author), Chloé Ackaert (Author), Juliana Bessa (Author), Campbell Bunce (Author), Timothy Hickling (Author), Vibha Jawa (Author), Mark A. Kroenke (Author), Kasper Lamberth (Author), Anaïs Manin (Author), Hweixian L. Penny (Author), Noel Smith (Author), Grzegorz Terszowski (Author), Sophie Tourdot (Author), Sebastian Spindeldreher (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A major impediment to successful use of therapeutic protein drugs is their ability to induce anti-drug antibodies (ADA) that can alter treatment efficacy and safety in a significant number of patients. To this aim, in silico, in vitro, and in vivo tools have been developed to assess sequence and oth...