Structure-based engineering of a novel CD3ε-targeting antibody for reduced polyreactivity

• Main Authors: Catherine Y Liu (Author), Cory L Ahonen (Author), Michael E Brown (Author), Ling Zhou (Author), Martin Welin (Author), Eric M Krauland (Author), Robert Pejchal (Author), Paul F Widboom (Author), Michael B Battles (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTBispecific antibodies continue to represent a growth area for antibody therapeutics, with roughly a third of molecules in clinical development being T-cell engagers that use an anti-CD3 binding arm. CD3 antibodies possessing cross-reactivity with cynomolgus monkey typically recognize a highl...