Modulating intestinal mucus barrier for nanoparticles penetration by surfactants

• Main Authors: Xin Zhang (Author), Wei Dong (Author), Hongbo Cheng (Author), Meixia Zhang (Author), Yongqiang Kou (Author), Jian Guan (Author), Qiaoyu Liu (Author), Mingyue Gao (Author), Xiuhua Wang (Author), Shirui Mao (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Improving peroral delivery efficiency is always a persistent goal for both small-molecule and macromolecular drug development. However, intestinal mucus barrier which greatly impedes drug-loaded nanoparticles penetration is commonly overlooked. Therefore, in this study, taking fluorescent labeled PL...