Can semipermeable membranes coating materials influence in vivo performance for paliperidone tri-layer ascending release osmotic pump tablet: In vitro evaluation and in vivo pharmacokinetics study

• Main Authors: Guangjing Li (Author), Yongjun Wang (Author), Hongming Chen (Author), Donglei Leng (Author), Panqin Ma (Author), Yanjie Dong (Author), Lifang Gao (Author), Zhonggui He (Author)
• Format: Book
• Published: Elsevier, 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One purpose of this study was to develop a paliperidone (PAL) tri-layer ascending release push-pull osmotic pump (TA-PPOP) tablet which could meet the needs of clinical applications. And another purpose was to investigate whether different coating materials influenced in vivo performance of TA-PPOP....