Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain

• Main Authors: Fangyu Du (Author), Ruolin Cao (Author), Lu Chen (Author), Jianwen Sun (Author), Yajie Shi (Author), Yang Fu (Author), Bruce D. Hammock (Author), Zhonghui Zheng (Author), Zhongbo Liu (Author), Guoliang Chen (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Soluble epoxide hydrolase (sEH) is related to arachidonic acid cascade and is over-expressed in a variety of diseases, making sEH an attractive target for the treatment of pain as well as inflammatory-related diseases. A new series of memantyl urea derivatives as potent sEH inhibitors was obtained u...