Moderate and high amounts of tamoxifen in αMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death

• Main Authors: Kevin Bersell (Author), Sangita Choudhury (Author), Mariya Mollova (Author), Brian D. Polizzotti (Author), Balakrishnan Ganapathy (Author), Stuart Walsh (Author), Brian Wadugu (Author), Shima Arab (Author), Bernhard Kühn (Author)
• Format: Book
• Published: The Company of Biologists, 2013-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Numerous mouse models have utilized Cre-loxP technology to modify gene expression. Adverse effects of Cre recombinase activity have been reported, including in the heart. However, the mechanisms associated with cardiac Cre toxicity are largely unknown. Here, we show that expression of Cre in...