New classes of potent heparanase inhibitors from ligand-based virtual screening

• Main Authors: Daniele Pala (Author), Laura Scalvini (Author), Gian Marco Elisi (Author), Alessio Lodola (Author), Marco Mor (Author), Gilberto Spadoni (Author), Fabiana F. Ferrara (Author), Emiliano Pavoni (Author), Giuseppe Roscilli (Author), Ferdinando M. Milazzo (Author), Gianfranco Battistuzzi (Author), Silvia Rivara (Author), Giuseppe Giannini (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heparanase is a validated target in cancer therapy and a potential target for several inflammatory pathologies. A ligand-based virtual screening of commercial libraries was performed to expand the chemical space of small-molecule inhibitors. The screening was based on similarity with known inhibitor...