Species Difference in the Contribution of T-Type Calcium Current to Cardiac Pacemaking as Revealed by R(−)-Efonidipine
The contribution of the T-type Ca2+ current to cardiac pacemaking was examined in isolated right atrial tissue from the mouse, guinea pig, and rabbit using a specific blocker, R(−)-efonidipine. At 10−6 M, R(-)-efonidipine produced negative chronotropy, which was prominent in the mouse and small but...
Saved in:
Main Authors: | Hikaru Tanaka (Author), Chisa Komikado (Author), Iyuki Namekata (Author), Hideki Nakamura (Author), Mariko Suzuki (Author), Yayoi Tsuneoka (Author), Koki Shigenobu (Author), Akira Takahara (Author) |
---|---|
Format: | Book |
Published: |
Elsevier,
2008-01-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The R(−)-Enantiomer of Efonidipine Blocks T-type but Not L-type Calcium Current in Guinea Pig Ventricular Myocardium
by: Hikaru Tanaka, et al.
Published: (2004) -
Involvement of the Na+/Ca2+ Exchanger in the Automaticity of Guinea-Pig Pulmonary Vein Myocardium as Revealed by SEA0400
by: Iyuki Namekata, et al.
Published: (2009) -
Developmental Changes in Action Potential Prolongation by K+-Channel Blockers in Chick Myocardium
by: Hideaki Nouchi, et al.
Published: (2011) -
Electrophysiological Effects of the Class Ic Antiarrhythmic Drug Pilsicainide on the Guinea-Pig Pulmonary Vein Myocardium
by: Akira Takahara, et al.
Published: (2012) -
New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles: Diversity in the Excitation-Contraction Mechanisms of the Heart
by: Hikaru Tanaka, et al.
Published: (2009)