Species Difference in the Contribution of T-Type Calcium Current to Cardiac Pacemaking as Revealed by R(−)-Efonidipine

• Main Authors: Hikaru Tanaka (Author), Chisa Komikado (Author), Iyuki Namekata (Author), Hideki Nakamura (Author), Mariko Suzuki (Author), Yayoi Tsuneoka (Author), Koki Shigenobu (Author), Akira Takahara (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The contribution of the T-type Ca2+ current to cardiac pacemaking was examined in isolated right atrial tissue from the mouse, guinea pig, and rabbit using a specific blocker, R(−)-efonidipine. At 10−6 M, R(-)-efonidipine produced negative chronotropy, which was prominent in the mouse and small but...