Species Difference in the Contribution of T-Type Calcium Current to Cardiac Pacemaking as Revealed by R(−)-Efonidipine

• Auteurs principaux: Hikaru Tanaka (Auteur), Chisa Komikado (Auteur), Iyuki Namekata (Auteur), Hideki Nakamura (Auteur), Mariko Suzuki (Auteur), Yayoi Tsuneoka (Auteur), Koki Shigenobu (Auteur), Akira Takahara (Auteur)
• Format: Livre
• Publié: Elsevier, 2008-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The contribution of the T-type Ca2+ current to cardiac pacemaking was examined in isolated right atrial tissue from the mouse, guinea pig, and rabbit using a specific blocker, R(−)-efonidipine. At 10−6 M, R(-)-efonidipine produced negative chronotropy, which was prominent in the mouse and small but...