Disulfiram thermosensitive in-situ gel based on solid dispersion for cataract

• Main Authors: Chunjuan Zhang (Author), Tonghua Xu (Author), Donglei Zhang (Author), Wei He (Author), Siling Wang (Author), Tongying Jiang (Author)
• Format: Book
• Published: Elsevier, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To improve the corneal permeability and water-solubility of disulfiram (DSF), which is an ocular drug for cataract, P188 was selected as a matrix to prepare solid dispersion of DSF (DSFSD) by hot melt method. The DSFSD was characterized by DSC, XRD, and IR, and the results suggested that DSF was amo...