Hepatocyte TRAF3 promotes insulin resistance and type 2 diabetes in mice with obesity

• Main Authors: Zheng Chen (Author), Mark J. Canet (Author), Liang Sheng (Author), Lin Jiang (Author), Yi Xiong (Author), Lei Yin (Author), Liangyou Rui (Author)
• Format: Book
• Published: Elsevier, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Metabolic inflammation is believed to promote insulin resistance and type 2 diabetes progression in obesity. TRAF3, a cytoplasmic signaling protein, has been known to mediate/modulate cytokine signaling in immune cells. The goal is to define the metabolic function of hepatic TRAF3 in the...