VCD-induced menopause mouse model reveals reprogramming of hepatic metabolism

• Main Authors: Roshan Kumari (Author), Michael E. Ponte (Author), Edziu Franczak (Author), John C. Prom (Author), Maura F. O'Neil (Author), Mihaela E. Sardiu (Author), Andrew J. Lutkewitte (Author), Lane K. Christenson (Author), Kartik Shankar (Author), E. Matthew Morris (Author), John P. Thyfault (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Menopause adversely impacts systemic energy metabolism and increases the risk of metabolic disease(s) including hepatic steatosis, but the mechanisms are largely unknown. Dosing female mice with vinyl cyclohexene dioxide (VCD) selectively causes follicular atresia in ovaries, leading to a...