Presence of antigen-experienced T cells with low grade of differentiation and proliferative potential in chronic Chagas disease myocarditis.

• Main Authors: Rafael J Argüello (Author), Carlos Vigliano (Author), Patricia Cabeza-Meckert (Author), Rodolfo Viotti (Author), Fernando Garelli (Author), Liliana E Favaloro (Author), Roberto R Favaloro (Author), Rubén Laguens (Author), Susana A Laucella (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The main consequence of chronic Trypanosoma cruzi infection is the development of myocarditis in approximately 20-30% of infected individuals but not until 10-20 years after the initial infection. We have previously shown that circulating interferon-γ-secreting T cells responsive to Trypanosoma cruz...