miR‐424‐5p reduces ribosomal RNA and protein synthesis in muscle wasting

• Main Authors: Martin Connolly (Author), Richard Paul (Author), Roser Farre‐Garros (Author), Samantha A. Natanek (Author), Susannah Bloch (Author), Jen Lee (Author), Jose P. Lorenzo (Author), Harnish Patel (Author), Cyrus Cooper (Author), Avan A. Sayer (Author), Stephen J. Wort (Author), Mark Griffiths (Author), Michael I. Polkey (Author), Paul R. Kemp (Author)
• Format: Book
• Published: Wiley, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background A loss of muscle mass occurs as a consequence of a range of chronic and acute diseases as well as in older age. This wasting results from an imbalance of protein synthesis and degradation with a reduction in synthesis and resistance to anabolic stimulation often reported features...