Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants

• Main Authors: Joana Magalhães (Author), Nina Franko (Author), Samanta Raboni (Author), Giannamaria Annunziato (Author), Päivi Tammela (Author), Agostino Bruno (Author), Stefano Bettati (Author), Stefano Armao (Author), Costanza Spadini (Author), Clotilde Silvia Cabassi (Author), Andrea Mozzarelli (Author), Marco Pieroni (Author), Barbara Campanini (Author), Gabriele Costantino (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance to antibacterial treatment and establish a long-lasting infection. In turn, this might lead to the onset of antimicrobial resistance that currently represents one of the most menacing threats to public health w...