Drug repurposing screening validated by experimental assays identifies two clinical drugs targeting SARS-CoV-2 main protease

• Main Authors: Denis N. Prada Gori (Author), Santiago Ruatta (Author), Martín Fló (Author), Lucas N. Alberca (Author), Carolina L. Bellera (Author), Soonju Park (Author), Jinyeong Heo (Author), Honggun Lee (Author), Kyu-Ho Paul Park (Author), Otto Pritsch (Author), David Shum (Author), Marcelo A. Comini (Author), Alan Talevi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The COVID-19 pandemic prompted several drug repositioning initiatives with the aim to rapidly deliver pharmacological candidates able to reduce SARS-CoV-2 dissemination and mortality. A major issue shared by many of the in silico studies addressing the discovery of compounds or drugs targeting SARS-...