MicroRNA199a-Based Post-transcriptional Detargeting of Gene Vectors for Hepatocellular Carcinoma

• المؤلفون الرئيسيون: Bijay Dhungel (مؤلف), Charmaine A. Ramlogan-Steel (مؤلف), Christopher J. Layton (مؤلف), Jason C. Steel (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2018-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

A gene therapeutic platform needs to be both efficient and safe. The criterion of safety is particularly important for diseases like hepatocellular carcinoma (HCC), which develop in a background of an already compromised liver. Gene vectors can be constructed either by targeting HCC or by detargetin...