Metabolism and Pharmacokinetics of the Anti-Tuberculosis Drug Ethionamide in a Flavin-Containing Monooxygenase Null Mouse

• Main Authors: Amy L. Palmer (Author), Virginia L. Leykam (Author), Andrew Larkin (Author), Sharon K. Krueger (Author), Ian R. Phillips (Author), Elizabeth A. Shephard (Author), David E. Williams (Author)
• Format: Book
• Published: MDPI AG, 2012-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multiple drug resistance (MDR) in Mycobacterium tuberculosis (mTB), the causative agent for tuberculosis (TB), has led to increased use of second-line drugs, including ethionamide (ETA). ETA is a prodrug bioactivated by mycobacterial and mammalian flavin-containing monooxygenases (FMOs). FMO2 is the...