Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system?

• Main Authors: Marijke eDe Bock (Author), Marianne eKerrebrouck (Author), Nan eWang (Author), Luc eLeybaert (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The coordination of tissue function is mediated by gap junctions (GJs) that enable direct cell-cell transfer of metabolic and electric signals. GJs are formed by connexins of which Cx43 is most widespread in the human body. In the brain, Cx43 GJs are mostly found in astroglia where they coordinate t...