TNF-α and CD8+ T cells mediate the beneficial effects of nitric oxide synthase-2 deficiency in pulmonary paracoccidioidomycosis.

• المؤلفون الرئيسيون: Simone Bernardino (مؤلف), Adriana Pina (مؤلف), Maíra Felonato (مؤلف), Tânia A Costa (مؤلف), Eliseu Frank de Araújo (مؤلف), Cláudia Feriotti (مؤلف), Silvia Boschi Bazan (مؤلف), Alexandre C Keller (مؤلف), Katia R M Leite (مؤلف), Vera L G Calich (مؤلف)
• التنسيق: كتاب
• منشور في: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

<h4>Background</h4>Nitric oxide (NO), a key antimicrobial molecule, was previously shown to exert a dual role in paracoccidioidomycosis, an endemic fungal infection in Latin America. In the intravenous and peritoneal models of infection, NO production was associated with efficient fungal...