TNF-α and CD8+ T cells mediate the beneficial effects of nitric oxide synthase-2 deficiency in pulmonary paracoccidioidomycosis.

• Main Authors: Simone Bernardino (Author), Adriana Pina (Author), Maíra Felonato (Author), Tânia A Costa (Author), Eliseu Frank de Araújo (Author), Cláudia Feriotti (Author), Silvia Boschi Bazan (Author), Alexandre C Keller (Author), Katia R M Leite (Author), Vera L G Calich (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Nitric oxide (NO), a key antimicrobial molecule, was previously shown to exert a dual role in paracoccidioidomycosis, an endemic fungal infection in Latin America. In the intravenous and peritoneal models of infection, NO production was associated with efficient fungal...