TNF-α and CD8+ T cells mediate the beneficial effects of nitric oxide synthase-2 deficiency in pulmonary paracoccidioidomycosis.

• Autori principali: Simone Bernardino (Autore), Adriana Pina (Autore), Maíra Felonato (Autore), Tânia A Costa (Autore), Eliseu Frank de Araújo (Autore), Cláudia Feriotti (Autore), Silvia Boschi Bazan (Autore), Alexandre C Keller (Autore), Katia R M Leite (Autore), Vera L G Calich (Autore)
• Natura: Libro
• Pubblicazione: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

<h4>Background</h4>Nitric oxide (NO), a key antimicrobial molecule, was previously shown to exert a dual role in paracoccidioidomycosis, an endemic fungal infection in Latin America. In the intravenous and peritoneal models of infection, NO production was associated with efficient fungal...