URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice

• Main Authors: Yoshiro Tanaka (Author), Tomohisa Nagoshi (Author), Hirotake Takahashi (Author), Yuhei Oi (Author), Akira Yoshii (Author), Haruka Kimura (Author), Keiichi Ito (Author), Yusuke Kashiwagi (Author), Toshikazu D. Tanaka (Author), Michihiro Yoshimura (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Accumulating evidence indicates that high uric acid (UA) is strongly associated with obesity and metabolic syndrome and drives the development of nonalcoholic fatty liver disease (NAFLD) and insulin resistance. Although urate transporter-1 (URAT1), which is primarily expressed in the kidn...