The anti-obesity effect of FGF19 does not require UCP1-dependent thermogenesis

• Main Authors: Patrick J. Antonellis (Author), Brian A. Droz (Author), Richard Cosgrove (Author), Libbey S. O'Farrell (Author), Tamer Coskun (Author), James W. Perfield, II (Author), Steven Bauer (Author), Mark Wade (Author), Tara E. Chouinard (Author), Joseph T. Brozinick (Author), Andrew C. Adams (Author), Ricardo J. Samms (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Fibroblast growth factor 19 (FGF19) is a postprandial hormone which plays diverse roles in the regulation of bile acid, glucose, and lipid metabolism. Administration of FGF19 to obese/diabetic mice lowers body weight, improves insulin sensitivity, and enhances glycemic control. The primar...