Restoring Prohealing/Remodeling-Associated M2a/c Macrophages Using ON101 Accelerates Diabetic Wound Healing

• Main Authors: Ching-Wen Lin (Author), Chih-Chiang Chen (Author), Wen-Yen Huang (Author), Yen-Yu Chen (Author), Shiou-Ting Chen (Author), Hung-Wen Chou (Author), Chien-Ming Hung (Author), Wan-Jiun Chen (Author), Chia-Sing Lu (Author), Shi-Xin Nian (Author), Shyi-Gen Chen (Author), Hsuen-Wen Chang (Author), Vincent H.S. Chang (Author), Li-Ying Liu (Author), Ming-Liang Kuo (Author), Shun-Cheng Chang (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetic wounds exhibit chronic inflammation and delayed tissue proliferation or remodeling, mainly owing to prolonged proinflammatory (M1) macrophage activity and defects in transition to prohealing/proremodeling (M2a/M2c; CD206+ and/or CD163+) macrophages. We found that topical treatment with ON10...