Safety, pharmacokinetics, and pharmacodynamics in healthy Chinese volunteers treated with SC0062, a highly selective endothelin‐A receptor antagonist

• Main Authors: Yun Liu (Author), Wei Wang (Author), Hongjie Qian (Author), Yuzhou Gui (Author), Yating Wang (Author), Rong Song (Author), Qian Chen (Author), Eric Rowinsky (Author), Sheng Wang (Author), Xiaoguang Liang (Author), Kaicun Gu (Author), Bo Zhou (Author), Weiwei Zhang (Author), Liqin Zhang (Author), Chen Yu (Author), Jingying Jia (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This study evaluated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and food effects (FE) of SC0062, a highly active endothelin‐A (ETA) receptor antagonist, in healthy subjects. The primary objectives of this first‐in‐human phase I study, comprised of single‐ascendi...