Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis

• Main Authors: Sandra Pérez-Baos (Author), Paula Gratal (Author), Juan I. Barrasa (Author), Ana Lamuedra (Author), Olga Sánchez-Pernaute (Author), Gabriel Herrero-Beaumont (Author), Raquel Largo (Author)
• Format: Book
• Published: BMC, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with their modification with tofacitinib (TOFA), at flare-up in antigen induced arthritis (AIA...